24. Response fluctuations in Parkinson’s disease

  1. Wearing off: a sudden, brief inability to start movement or to continue repeated movements?
  2. Protein related offs: trans­port of levodopa across the intestinal wall is decreased because of competition for facilitated transport by large amounts of neutral amino acids?
  3. Delayed on: a prolongation of the time required for levodopa effect to appear?
  4. Peak-dose dyskinesias: occurs at the time of peak levodopa plasma concentrations?
  5. Freezing: reemergence of parkinsonian symptoms before the next scheduled levodopa dose?
  6. Diphasic dyskinesia: a dyskinesia in which involuntary movements occur during both peak and trough levodopa concentrations?

  1. F
  2. T
  3. T
  4. T
  5. F
  6. T