Tag: Drugs

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86. GABA GABA hey

  1. GABA, γ-Aminobutyric acid, is the principal inhibitory neurotransmitter in the human central nervous system. (T/F?)
  2. GABA synthesis starts from glutamate which is the second most abundant inhibitory neurotransmitter in the CNS. (T/F?)
  3. GABAA receptor is a G protein-coupled receptor. (T/F?)
  4. GABAB receptor is part of a ligand-gated ion channel complex. (T/F?)
  5. Pregabalin and gabapentin are GABA reuptake inhibitors. (T/F?)
  6. Valproate is a GABA-transaminase inhibitor. (T/F?)

  1. T
  2. F
  3. F
  4. F
  5. F
  6. T

 

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24. Response fluctuations in Parkinson’s disease

  1. Wearing off: a sudden, brief inability to start movement or to continue repeated movements?
  2. Protein related offs: trans­port of levodopa across the intestinal wall is decreased because of competition for facilitated transport by large amounts of neutral amino acids?
  3. Delayed on: a prolongation of the time required for levodopa effect to appear?
  4. Peak-dose dyskinesias: occurs at the time of peak levodopa plasma concentrations?
  5. Freezing: reemergence of parkinsonian symptoms before the next scheduled levodopa dose?
  6. Diphasic dyskinesia: a dyskinesia in which involuntary movements occur during both peak and trough levodopa concentrations?

  1. F
  2. T
  3. T
  4. T
  5. F
  6. T