- Pyridostigmine is a reversible acetylcholinesterase inhibitor?
- Amifampridine blocks potassium channel efflux in nerve terminals which increases duration of the action potential?
- Aminoglycoside antibiotics can aggravate myasthenia gravis (MG) ?
- Patients with MG show decreased susceptibility to depolarizing neuromuscular blocking agents ?
- Patients with MG show increased susceptibility to non-depolarizing neuromuscular blocking agents?
- Patients with Lambert-Eaton myasthenic syndrome show decreased susceptibility to both depolarizing and non-depolarizing neuromuscular blockers?
34. Diagnosis of myasthenia gravis
- The titer of anti-AChR antibodies in patients with myasthenia gravis (MG) closely matches the severity of symptoms?
- The sensitivity of anti-AChR antibodies with pure ocular MG is between 85 – 90% ?
- Repetitive nerve stimulation typically shows decremental response in MG?
- Repetitive nerve stimulation typically shows facilitation in Lambert-Eaton myasthenic syndrome?
- Single-fiber electromyography is the most sensitive test for MG?
- Subjective improvement in muscular weakness after intravenous edrophonium is considered as positive Tensilon test and confirmation of MG ?
33. Antibodies in myasthenia gravis
- Antibodies against the nicotinic acetylcholine receptor (AChR) are found in 50 – 60% of patients with generalized myasthenia gravis (MG)?
- A majority of antibodies against the AChR found in patients with MG are “blocking” antibodies which prevent binding of acetylcholine to the AChR?
- Anti-AChR “binding” antibodies, bind to the AChR and cause destruction of junctional folds by activating the complement system?
- Most of the seronegative MG patient (those that do not have anti-AChR antibodies but have MG) have antibodies against P/Q-type VGCC (voltage gated-calcium channels)?
- Antibodies against LRP4, Agrin and titin proteins are shown in some seronegative MG patients ?
- Patients that have anti-MuSK (Muscle-Specific Kinase) antibodies suffer from Lambert–Eaton myasthenic syndrome?