Tag: GABA

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86. GABA GABA hey

  1. GABA, γ-Aminobutyric acid, is the principal inhibitory neurotransmitter in the human central nervous system. (T/F?)
  2. GABA synthesis starts from glutamate which is the second most abundant inhibitory neurotransmitter in the CNS. (T/F?)
  3. GABAA receptor is a G protein-coupled receptor. (T/F?)
  4. GABAB receptor is part of a ligand-gated ion channel complex. (T/F?)
  5. Pregabalin and gabapentin are GABA reuptake inhibitors. (T/F?)
  6. Valproate is a GABA-transaminase inhibitor. (T/F?)

  1. T
  2. F
  3. F
  4. F
  5. F
  6. T

 

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16. GABAergic cells of the cerebellum

  1. Purkinje cells, one of the largest neurons in the brain, exert inhibitory effects on their targets and use GABA as their neurotransmitter?
  2.  Cerebellar Golgi cells are located in the granular layer of the cerebellum and they use GABA as their neurotransmitter?
  3. Cerebellar stellate cells are inhibitory interneurons located in the  molecular layer of the cerebellum and they use GABA as their neurotransmitter?
  4. Unipolar brush cells (UBCs) are a class of inhibitory  interneurons found in the granular layer of the cerebellar cortex which use GABA as their neurotransmitter?
  5. Cerebellar basket cells synapse on the cell bodies of Purkinje cells, exert inhibitory effect on them, and use GABA as their neurotransmitter?
  6. Cerebellar granule cells are the most numerous neurons in the brain, they use glutamate as their neurotransmitter  and  exert excitatory effects on their targets?

  1. T
  2. T
  3. T
  4. F
  5. T
  6. T

  1. Unipolar brush cells (UBCs) are excitatory glutamatergic interneurons. They can be found the granular layer of the cerebellar cortex but also in the cochlear nucleus in the brainstem.