Tag: Genetics

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9. Etiology of MS

  1. The concordance rate for a clinical diagnosis of the disease in identical twins is about 30%. (T/F?)
  2. Adoptive children, when raised from infancy in families with a high prevalence of the disease, have three times greater incidence of the disease then the general population. (T/F?)
  3. It is associated with both MHC and HLA antigens. (T/F?)
  4. Low levels of vitamin D have not been associated with an increased risk for the disease. (T/F?)
  5. Smoking is an independent risk factor. (T/F?)
  6. History of infectious mononucleosis, as opposed to the asymptomatic EBV infection,  does not  implicate greater risk for  the disease. (T/F?)

  1. T
  2. F
  3. T
  4. F
  5. T
  6. F

  1. Such adoptive children have a risk for developing multiple sclerosis similar to the general population.
  1. Low levels of vitamin D have been associated with an increased risk for multiple sclerosis.
  1. The risk for developing MS is lower in people who are seronegative for EBV.