- Pyridostigmine is a reversible acetylcholinesterase inhibitor?
- Amifampridine blocks potassium channel efflux in nerve terminals which increases duration of the action potential?
- Aminoglycoside antibiotics can aggravate myasthenia gravis (MG) ?
- Patients with MG show decreased susceptibility to depolarizing neuromuscular blocking agents ?
- Patients with MG show increased susceptibility to non-depolarizing neuromuscular blocking agents?
- Patients with Lambert-Eaton myasthenic syndrome show decreased susceptibility to both depolarizing and non-depolarizing neuromuscular blockers?
35. Neuromuscular junction
- When action potential arrives at the presynaptic neuron terminal, voltage-dependent calcium channels open and calcium ions flow from the extracellular fluid into the neuron?
- Influx of calcium into the neuron triggers the fusion of acetylcholine vesicles with the membrane and the release of ACh into the synaptic cleft?
- Nicotinic and muscarinic ACh receptors (AChRs) are ligand-gated ion channels?
- The binding of ACh to nicotinic AChR in the postsynaptic muscle membrane opens a calcium channel within the receptor allowing calcium influx and depolarization of the muscle membrane?
- Two ACh molecules must bind with each AChR to open its channel?
- Choline acetyltransferase in the synaptic cleft decomposes ACh into choline and acetic acid?